Azilect Disease Interactions
There are 5 disease interactions with Azilect (rasagiline).
Dopamine agonists (applies to Azilect) hypotension
Major Potential Hazard, Moderate plausibility.
Dopamine agonists may impair the systemic regulation of blood pressure, with resultant orthostatic hypotension, especially during dose escalation. Therapy with dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.
References
- Hoehn MM (1975) "Levodopa-induced postural hypotension. Treatment with fludrocortisone." Arch Neurol, 32, p. 50-1
- Iwasaki S, Hamaguchi K, Iwasaki A, Takakusagi M, Narabayashi Y (1990) "Hypotensive effect of long-term levodopa in patients with Parkinson's disease." Eur Neurol, 30, p. 194-9
- (2001) "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn
- (2001) "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals
- (2001) "Product Information. Sinemet CR (carbidopa-levodopa)." DuPont Pharmaceuticals
- (2001) "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim
- (2001) "Product Information. Requip (ropinirole)." SmithKline Beecham
- (2001) "Product Information. Comtan (entacapone)." Novartis Pharmaceuticals
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
- (2007) "Product Information. Neupro (rotigotine)." Schwarz Pharma
- (2017) "Product Information. Xadago (safinamide)." US WorldMeds LLC
Dopaminergic antiparkinson agents (applies to Azilect) psychosis
Major Potential Hazard, Moderate plausibility.
Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis. Hallucinations and psychotic-like behavior have been reported with dopaminergic medications. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of these drugs.
References
- (2001) "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn
- (2001) "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim
- (2001) "Product Information. Requip (ropinirole)." SmithKline Beecham
- (2001) "Product Information. Comtan (entacapone)." Novartis Pharmaceuticals
- (2001) "Product Information. Lodosyn (carbidopa)." DuPont Pharma
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
- (2007) "Product Information. Neupro (rotigotine)." Schwarz Pharma
- (2017) "Product Information. Xadago (safinamide)." US WorldMeds LLC
Rasagiline (applies to Azilect) hepatic impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Rasagiline should not be used in patients with moderate to severe hepatic impairment. Patients with mild hepatic impairment should not exceed a dose of 0.5 mg daily.
References
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
Rasagiline (applies to Azilect) hypertension
Moderate Potential Hazard, Moderate plausibility.
Exacerbation of hypertension may occur during treatment with rasagiline. Dosage adjustment may be necessary if the elevation is sustained. Patients should be monitored for new onset hypertension or hypertension that is not well controlled after starting treatment.
References
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
Rasagiline (applies to Azilect) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Dose adjustment of rasagiline is not required for patients with mild or moderate renal impairment. However, rasagiline has not been studied in patients with severe renal impairment. Caution is advised if used.
References
- (2006) "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA
Azilect drug interactions
There are 510 drug interactions with Azilect (rasagiline).
Azilect alcohol/food interactions
There are 4 alcohol/food interactions with Azilect (rasagiline).
More about Azilect (rasagiline)
- Azilect consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (10)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- FDA approval history
- Drug class: dopaminergic antiparkinsonism agents
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.